Synthesis, Spectroscopic Analysis, and In Vitro Anticancer Evaluation of 2-(Phenylsulfonyl)-2H-1,2,3-triazole

The 1,2,3-Triazole derivatives containing the sulfonyl group have proved their biological importance in medicinal chemistry and drug design. In this sense, we describe regioselective synthesis of 2-(phenylsulfonyl)-2H-1,2,3-triazole 3 good yield through a classical sulfonamidation reaction 1H-1,2,3-triazole 1 with benzenesulfonyl chloride 2 dichloromethane using slight excess triethylamine at 20 °C for h. This procedure is distinguished by its short time, high yield, excellent regioselectivity, clean profile, operational simplicity. sulfonamide was characterized high-resolution mass spectrometry, FT–IR, UV–Vis, 1D 2D NMR spectroscopy, elemental analysis. exhibited moderate activity against UO-31 renal, SNB-75 central nervous system, HCT-116 colon, BT-549 breast cancer cell lines, growth inhibition percentages (GI%) ranging from 10.83% to 17.64%.